Cognitive functions and neurotropic factors associated with aging: A review
Abstract
RESEARCH OBJECTIVE: The aim of the present article was to make a narrative review about the relation of cognitive functions and neurotrophic factors with aging.
THE RESEARCH PROBLEM AND METHODS: The research problem concerns the issue of aging and the changes in cognitive and biochemical functioning that may occur in this process. The article uses the method of critical analyzes as well as the analyzes of the reference literature.
THE PROCESS OF ARGUMENTATION: The first section of the article discusses population aging, the second addresses changes related to cognitive functions during aging. The third part show biochemical aspects that can directly influence the cognitive functions already mentioned, and on aging in general.
RESEARCH RESULTS: The result of this review points out that the world population is aging in an accelerated way and during this process of aging there are several changes in the organism of the elderly, among which stand out the cognitive and biochemical, one being directly related to the other. In this case, there is a relation of the neurotrophic factors, which may be responsible for the changes in cognitive functions, specifically spatial memory alterations.
CONCLUSIONS, INNOVATIONS AND RECOMMENDATIONS: It is necessary that more studies be carried out with this population, which may trace the elderly with cognitive impairment that may be suggestive or conclusive of a neurodegenerative disease. In addition, biochemical data may contribute to the search for new therapeutic models or early identification for Alzheimer’s disease or other associated dementias.
References
Appel, S.H. (1981). A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer disease. Annals of Neurology, 10, 499‑505. Retrieved from: http://onlinelibrary.wiley.com/journal/10.1002/ (ISSN)1531‑8249.
Argimon, I.I.L. & Stein, L.M. (2005). Habilidades cognitivas em indivíduos muito idosos: um estudo longitudinal. Caderno de Saúde Pública, 21(1), 64‑72. Retrieved from: http://dx.doi.org/10.1590/S0102‑311X2005000100008.
Banhato, E.F.C. & Nascimento, E. (2007). Função executiva em idosos: um estudo utilizando subtestes da Escala WAIS-III. Psico-USF, 12(1), 65‑73.
Retrieved from: www.scielo.br/pdf/pusf/v12n1/v12n1a08.pdf. Barrientos, R.M., Kitt, M.M., Watkins, L.R., & Maier, S.F. (2015). Neuro inflammation in the normal aging hippocampus. Neuroscience, 19(309), 84‑99. DOI: 10.1016/j.neuroscience.2015.03.007.
Brailean, A., Huisman, M., Prince, M., Prina, A.M., Deeg, D.J.H., & Comijs, H. (2016). Cohort Differences in Cognitive Aging in the Longitudinal Aging Study Amsterdam. The Journals of Gerontology Series B Psychological Sciences and Social Sciences, 00(00), 1‑10. Retrieved from: https://doi.org/10.1093/ geronb/gbw129.
Brasil. (2006). Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Política nacional de atenção básica/ Ministério da Saúde, Secretaria de Atenção à Saúde, Departamento de Atenção à Saúde. – Brasília: Ministério da Saúde. Retrieved from: http://portalsaude.saude.gov.br.
Brayne, C.O. (2007). The elephant in the room – healthy brains in later life, epidemiology and public health. Nature Review Neuroscience, 8, 233‑239. DOI:10.1038/nrn209.
Budni, J., Bellettini-Santos, T., Mina, F., Garcez, M.L., & Zugno, A.I. (2015). The involvement of BDNF, NGF and GDNF in aging and Alzheimer’s disease. Aging and Disease, 6(5), 331‑341. DOI: 10.14336/AD.2015.0825.
Burke, S.N. & Barnes, C.A. (2006). Neural plasticity in the ageing brain. Nature Reviews Neuroscience, 7, 30‑40. DOI: 10.1038/nrn1809.
Cagnin, A., Bussè, C., Jelcic, N., Gnoato, F., Mitolo, M., & Caffara, P. (2015). High specificity of MMSE pentagon scoring for diagnosis of prodromal dementia with Lewy bodies. Parkinsonism and Related Disordes, 21, 303‑305. DOI:10.1016/j.parkreldis.2014.12.007.
Camarano, A.A. (2002). Envelhecimento da população brasileira: uma contribuição demográfica. Rio de Janeiro: Instituto de Pesquisa Econômica Aplicada. Retrieved from: www.ipea.gov.br/agencia/images/stories/PDFs/TDs/td_0858.pdf.
Cirulli, F. & Alleva, E. (2009). The NGF saga: from animal models of psychosocial stress to stress-related psychopathology. Frontiers in Neuroendocrinology, 30, 379‑395. DOI: 10.1016/j.yfrne.2009.05.002.
Coutinho, G., Mattos, P., & Abreu, N. (2010). Atenção. In: D. Malloy-Dinniz, Fuentes, P. Mattos, N. Abreu et al. Avaliação Neuropsicológica. 1ª ed. Porto Alegre: Artmed.
Dani, A.V. (2012). Estudo das funções executivas no envelhecimento bem-sucedido. Porto Alegre. 47 p. Monografia (Especialização em neuropsicologia) Instituto de Psicologia, Universidade Federal do Rio Grande do Sul.
Decoster, L., Van Puyvelde, K., Mohile, S., Wedding, U., Basso, U., Colloca, G., Rostoft, S., Overcash, J., Wildiers, H., Steer, C., Kimmick, G., Kanesvaran, R., Luciani, A., Terret, C., Hurria, A., Kenis, C., Audisio, R., & Extermann, M. (2015). Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: An update on SIOG recommendations. Annals of Oncology, 26, 288‑300. DOI: 10.1093/annonc/mdu210.
Extermann-Guilloux, G., Guilloux, J.P., Lewis, D.A., & Sibille, E. (2013). Anticipated
brain molecular aging in major depression. The American Journal of Geriatric Psychiatry, 21, 450‑460. DOI: 10.1016/j.jagp.2013.01.040.
Fuentes, D., Malloy-Dinniz, L., de Camargo, C.H.P., & Cosenza, R.M. (2014). Neuropsicologia: teoria e prática. 2ª ed. Porto Alegre: Artmed.
Gad, A.M. (2011). Executive function and instrumental activities of daily living in MCI and AD. Alzheimer’s & Dementia, 7(3), 300‑308. DOI: 10.1016/j. jalz.2010.04.005.
Ganguli, M., Snitz, B.E., Saxton, J.A., Chang, C-C.H., Lee, C.W., Vander Bilt, J., Hughes, T.F., Loewenstein, D.A., Unverzagt, F.W., & Petersen, R.C. (2011).
Outcomes of mild cognitive impairment depend on definition: a population study. Archives of Neurology, 68(6), 761‑767. DOI: 10.1001/archneurol.2011.10.
Gooney, M., Messaoudi, E., Maher, F.O., Bramham, C.R., & Lynch, M.A. (2004). BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events. Neurobiology Aging, 25, 1323‑1331. DOI: http://dx.doi. org/10.1016/j.neurobiolaging.2004.01.003.
Gorestein, C., Wang, Y.P., & Hungerbuhler, I. (2016). Instrumentos de avaliação em saúde mental. Porto Alegre: Artmed.
Hillis, A.E. (2007). Aphasia: progress in the last quarter of a century. Neurology, 69(2), 200‑213. DOI: 10.1212/01.wnl.0000265600.69385.6f.
Hock, C., Heese, K., Hulette, C., Rosenberg, C., & Otten, U. (2000). Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Archives of Neurology, 57, 846‑851. DOI: 10.1001/archneur.57.6.846.
Holsinger, R.M., Schnarr, J., Henry, P., Castelo, V.T., & Fahnestock, M. (2000). Quantitation of BDNF mRNA in human parietal cortex by competitive reverse
transcription-polymerase chain reaction: decreased levels in Alzheimer’s disease. Molecular Brain Research, 76, 347‑354. Retrieved from: https://doi. org/10.1016/S0169‑328X(00)00023‑1.
Instituto Brasileiro de Geografia e Estatística (BR). (2010). Indicadores sociais. Censo Demográfico. Rio de Janeiro, IBGE, 2010.
Jacinto, A.F. (2008). Alterações cognitivas em idosos atendidos em ambulatório
geral de clínica médica. 105p. Tese (Doutorado em Ciências). Faculdade de Medicina, Universidade de São Paulo.
Jonker, C., Geerlings, M.I., & Schmand, B. (2000). Are memory complaints predictive for dementia? A review of clinical and population-based studies. International Journal of Geriatric Psychiatry, 15(11), 983‑991. DOI:10.1002/1099‑1166(200011)15:11<983::AID-GPS238>3.0.CO;2‑5.
Kang, H. & Schuman, E.M. (1995). Long-lasting neurotrophin-induced enhancement
of synaptic transmission in the adult hippocampus. Science, 267, 658‑1662. DOI: 10.1126/science.7886457.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenenh, & Bonhoeffer, T. (1995). Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proceedings of the National Academy of Sciences of the United States of America, 92, 8856‑8860. Retrieved from: http://www.pnas.org.
Levi-MontalcinI, R. & Angeletti, P.U. (1968). Nerve growth factor. Physiological Reviews, 48, 534‑569. Retrieved from: http://physrev.physiology.org.
Lezak, M.D., Howieson, D.B., Bigler, E.D., & Tranel, D. (2012). Avaliação Neuropsicológica. 5ª ed. New York: Oxford, 2012.
Lima, N.M.F.V., Servelhere, K.R., & Matos, A.R. (2012). O perfil das Apraxias na doença de Alzheimer. Ensaios e Ciências Ciências Biológicas e da Saúde, 16(1), 1‑8. Retrieved from: http://arquivos.info.ufrn.br/arquivos/.../Artigo_apraxias.pdf.
López-Otín, C., Blasco, M.A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The
Hallmarks of Aging. Cell, 153(6), 1194‑1217. DOI: 10.1016/j.cell.2013.05.039. Mansur, L. (2010). Linguagem. In: Malloy-Dinniz, D. Fuentes, P. Mattos, N. Abreu et al., Avaliação Neuropsicológica. 1ª ed. Porto Alegre: Artmed, p. 67.
Mattos, P. & Paixão Junior, C.M. (2010). Avaliação Cognitiva de Idosos: Envelhecimento e comprometimento cognitivo leve. In: Malloy-Diniz et al., Avaliação
Neuropsicológica. 1 ed. Porto Alegre: Artmed, 247‑252.
Mattson, M.P., Chan, S.L., & Duan, W. (2002). Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiological Reviews,
, 637‑672. DOI: 10.1152/physrev.00004.2002.
Mcallister, A.K., Katz, L.C., & LO, D.C. (1999). Neurotrophins and synaptic plasticity. Annual Review of Neuroscience, 22, 295‑318. DOI: 10.1146/annurev.neuro.22.1.295.
Mejia-Arango, S. & Gutierrez, L.M. (2011). Prevalence and Incidence Rates of Dementia and Cognitive Impairment No Dementia in the Mexican Population: Data from the Mexican Health and Aging Study. Journal of Aging and Health, 23(7), 1050‑1074. DOI: 10.1177/0898264311421199.
Mesulam, M.M. (2000). Principles of Behavioral and Cognitive Neurology. 2ª ed. Oxford: Oxford University Press.
Morrison, J.H. & Baxter, M.G. (2012). The ageing cortical synapse: hallmarks and implications for cognitive decline. Nature Review Neuroscience, 13(4), 240‑250. DOI: 10.1038/nrn3200.
Murman, D.L. (2015). O impacto da idade sobre Cognição. Semin Hear, 36(3), 111‑112.
Niewiadomska, G., Mietelska-Porowska, A., & Mazurkiewicz, M. (2011). The cholinergic system, nerve growth factor and the cytoskeleton. Behavior Brain Research, 221, 515‑526. DOI: 10.1016/j.bbr.2010.02.024.
Nihtila, E.K., Martikainen, P.T., Koskinen, S.V.P., Reunanen, A.R., Noro, A.M. & Häkkinen, U.T. (2007). Chronic conditions and the risk of long-term institutionalization
among older people. European Journal of Public Health, 18(1), 77‑84. DOI: 10.1093/eurpub/ckm025.
Oliveira, P.B. de & Tavares, D.M.S. (2014). Condições de saúde de idosos residentes em Instituição de Longa Permanência segundo necessidades humanas básicas. Revista Brasileira de Enfermagem, 67(2), 241‑246. DOI 10.5935/0034‑7167.20140032.
Organización Mundial de la Salud, Organización Panamericana de la Salud. (1998). Salud de las personas de edad: envejecimiento y salud: un cambio de paradigma: 122ª sección. Washington (USA): OMS/OPAS.
Pang, P.T. & Lu, B. (2004). Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF. Ageing Research Reviews, 3, 407430. DOI: 10.1016/j.arr.2004.07.002.
Peltzer, K. & Phaswana-Mafuya, N. (2012). Cognitive functioning and associated factors in older adults in South Africa. South African Journal of Psychiatry, 18,
‑163. DOI:10.7196/SAJP.368.
Ramos, L.M.B.C., Rocha, M.I., Gomes, I., & Schwanke, C.H.A. (2012). Tradução e adaptação cultural do APQ – Aging Perceptions Questionnarie para a língua portuguesa brasileira. Revista Brasileira de Geriatria e Gerontologia, 15(2), 233‑242. http://dx.doi.org/10.1590/S1809‑98232012000200006.
Reid, L.M. & MacLullich, A.M.J. (2006). Subjective memory complaints and cognitive impairment in older people dement. Dementia and Geriatric Cognitive Disorders, 22(5‑6), 471‑85. DOI: 10.1159/000096295.
Rex, C.S., Kramár, E.A., Colgin, L.L., Lin, B., Gall, C.M., & Lynch, G. (2005). Long-term potentiation is impaired in middle-aged rats: regional specificity and reversal by adenosine receptor antagonists. Journal Neuroscience, 25, 5956‑5966. DOI: 10.1523/JNEUROSCI.0880‑05.2005.
Miyagawa, T. & Iwata A. (2016). [Subjetive memory complaints (SMC)]. Nihon Rinsho, 74(3), 451‑454.
Royall, D.R., Lauterbach, E.C., Cymmings, J.L., Reeve, A., Rummans, T.A., Kaufer, D.I., LaFrance, W.C.Jr., & Coffey, C.E. (2002). Executive control function: a review of its promise and challenges for clinical research – a report from the committee on research of the American Neuropsychiatric Association. The Journal of Neuropsychiatry & Clinical Neurosciences, 14, 377‑405. DOI: 10.1176/jnp.14.4.377.
Salles, J.F. & Rodrigues, J.C. (2014). Neuropsicologia da Linguagem. In: D. Fuentes,
L.F. Malloy-Dinniz, C.H.P. Camargo, R.M. Cosenza, Neuropsicologia: teoria e prática. 2ª ed. Porto Alegre: Artmed.
Santos, F.H., Andrade, V.M., & Bueno, O.F.A. (2009). Envelhecimento: um processo multifatorial. Psicologia em Estudo, Maringá, 14(1), 3‑10.
Sanvito, W.L. (2010). Propedeutica neurológica básica. 2ª ed. São Paulo: Atheneu. Siegel, G.J. & Chauhan, N.B. (2000). Neurotrophic factors in Alzheimer’s and Parkinson’s disease brain. Brain Research Reviews, 33, 99‑227. Retrieved from: https://doi.org/10.1016/S0165‑0173(00)00030‑8.
Sohrabji, F. & Lewis, D.K. (2006). Estrogen–BDNF interactions: implications for neurodegenerative diseases. Frontiers in Neuroendocrinology, 27, 404‑414. DOI: 10.1016/j.yfrne.2006.09.003.
Tapia-Arancibia, L., Aliaga, E., Silhol, M., & Arancibia, S. (2008). New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Research Review, 59, 201‑20. DOI: 10.1016/j.brainresrev.2008.07.007.
Vigneu, M., Beacousin, V., Hervé, P.Y., Duffau, H., Crivello, F., Houde, Ó., Mazoyer, B., & Tzourio-Mazoyer, N. (2006). Meta-analyzing left hemisphere language areas: Phonology, semantics, and sentence processing. NeuroImage, 30(4), 1414‑1432. DOI: 10.1016/j.neuroimage.2005.11.002.
Wheaton, L.A. & Hallett, M. (2007). Ideomotor apraxia: a review. Journal of the Neurological Sciences, 260, 1‑10. DOI: 10.1016/j.jns.2007.04.014.
Wisdom, N.M., Mignogna, J., & Collins, R.L. (2012). Variability in Wechsler Adult Intelligence Scale-IV Subtest Performance Across Age. Archives of Clinical Neuropsychology, 27, 389‑397. DOI: 10.1093/arclin/acs041. Epub 2012 Apr 17.
Woodruff-Pak, D.S. (1997). The Neuropsychology of aging. Malden: Blawell Plublishers.
Yourman, L.C., Lee, S.J., & Schonberg, M.A. (2012). Prognostic indices for older adults: A systematic review. JAMA: The Journal of the American Medical Association,
, 182‑92. DOI: 10.1001/jama.2011.1966.
Zuccolo, P.F., Rzezal, P. & Góis, J.O. (2014). Praxia e Visuoconstrução. In: D. Fuentes, L.F. Malloy-Dinniz, C.H.P. Camargo, R.M. Cosenza, Neuropsicologia: teoria e prática. 2ª ed. Porto Alegre: Artmed.
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